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Matrix repair is impaired in the avascular IVD, resulting in weakening and increased vulnerability to damage by physiologic loading

Several hundred peer-reviewed studies, the majority in rats, covering tendon, ligament, muscle, gut, vascular, and central nervous system injury models

10.1016/j.ejmech.2018.09.027 301 WangX.-M.LiuX.-M.WangY.ChenZ.-Y

But the biggest challenge for the acetate form is pH sensitivity

However, vitamin injections require administration by a healthcare professional, which can minimize the risk of incorrect dosing and potential side effects

Mild water retention: Occasional during the first weeks, typically resolving as the cycle progresses